Author

Sabine Lagger

University of Veterinary Medicine ViennaORCID 0000-0002-3032-9910Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Boris TichýiD· 2 shared Christina SternbergiD· 2 shared Desiree Lindner· 2 shared Felix SternbergiD· 2 shared Gerda EggeriD· 2 shared Heidi Anne NeubaueriD· 2 shared Jenny Liao PerssoniD· 2 shared Karolína TrachtováiD· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Boris TichýORCID

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3 papers

Recent·Most cited

Cancer BiologyMolecular CancerPeer-reviewedOct 31, 2024

Cell-autonomous GP130 activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

Christina Sternberg, Martin Raigel, Tanja Limberger…·Lukas Kenner

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

17 citations

humanbulk RNA-seq

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Cancer BiologyMolecular CancerPeer-reviewedMay 29, 2024

JUN mediates senescence and immune cell recruitment to prevent prostate cancer progression

Torben Redmer, Martin Raigel, Christina Sternberg…·Lukas Kenner

This study shows JUN suppresses prostate cancer progression by inducing senescence and immune cell recruitment, with JUN depletion accelerating tumor growth.

39 citationstop 3%

mousebulk RNA-seq

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Molecular BiologyPLoS GeneticsPeer-reviewedMay 12, 2017

Domains of methylated CAC and CG target MeCP2 to tune transcription in the brain

Sabine Lagger, John C. Connelly, Gabriele Schweikert…·Adrian Peter Bird

The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.

146 citationstop 1%

mouseDNA methylation

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