Chih‐Jen Cheng

This paper introduces dodecagon light-sheet fluorescence microscopy (dodecaLSFM) to eliminate striping artifacts in large-volume imaging, demonstrating its effectiveness in imaging whole mouse brain vasculature and combining with expansion microscopy for 3D cellular resolution.

This study shows that ER-mitochondria disconnection in ADPKD causes metabolic reprogramming and cyst formation, and restoring this connection reduces disease symptoms.

This paper develops an extracellular flux analysis to study mitochondrial respiration and energy metabolism in isolated renal tubules, showing transport activity regulates mitochondrial bioenergetics and biogenesis.