Johannes Morstein

This study explores targeting the LRRK2 GTPase domain as an alternative to kinase inhibitors to reduce kinase activity with less toxicity.

This paper develops a method to selectively manipulate and functionalize specific lipid classes in living cells using synthetic lipid analogs and bifunctional lipids.

This study introduces light-sensitive sphingosines (caSphs) that allow reversible control of sphingolipid biosynthesis through photo-isomerization, enabling precise manipulation of lipid production in living cells.

This paper develops spatially restricted antagonists to selectively inhibit β1AR signaling at the plasma membrane versus intracellular compartments, revealing compartment-specific effects on downstream signaling.

The paper identifies a mechanism where post-synaptic mushroom body neurons generate carbon monoxide to induce localized dopamine release from presynaptic terminals, facilitating memory-related plasticity.