Xiangyang Chen

The paper identifies two novel proteins, EGC-2 and EGC-3, that are essential for E granule assembly and small RNA homeostasis in C. elegans using TurboID-based proximity labeling and RNAi screening.

This study shows that rRNA intermediates influence nucleolar structure in C. elegans by altering protein distribution and causing architectural changes.

The paper identifies subcompartments within C. elegans germ granules and maps perinuclear proteins to specific regions, revealing a novel D granule and the role of MIP-1/EDDG-1 in germ granule architecture.

The paper identifies peri-centrosomal localization of siRNAs in C. elegans using NRDE-3 as a reporter, showing dependence on 22G siRNAs and centrosomal components.

The paper identifies a new subcompartment in C. elegans germ granules that facilitates specialized small RNA production, essential for fertility and RNAi response.

The paper systematically characterizes chromodomain proteins in C. elegans, identifying CEC-5 as an H3K9me1/2 reader that regulates aging through interactions with MET-2.

The paper identifies a ZTF-7/RPS-2 complex involved in C. elegans' response to cold-warm temperature changes by regulating RNA exosome localization.

The paper identifies factors involved in risiRNA generation in C. elegans and shows their role in rRNA surveillance through exosome and nucleolar RNAi mechanisms.

The paper identifies CDE-1 as a factor that suppresses risiRNA production by polyuridylating and degrading 26S rRNA in C. elegans.

The paper identifies WAGO-4, a cytoplasmic Argonaute protein, as essential for the inheritance of RNAi in C. elegans, showing its role in translocating to the germline and binding 22G-RNAs.