Volker Kinast

This study reveals that the ISG Shiftless (SHFL) has both antiviral and proviral functions during coronavirus infection, enhancing susceptibility while modulating IFN signaling.

This study examines how different HEV HVR insertion variants affect host transcriptomic responses in PHHs, finding that HVR duplication variants elicit weaker host responses and reduced ISG induction.

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

This study identifies lysosomal cathepsins, particularly CTSL, as critical for HEV entry and demonstrates the antiviral efficacy of the pan-cathepsin inhibitor K11777.