Jeffrey L. Brodsky

This study shows that GRP170 protects podocytes from stress-induced glomerular injury by modulating the UPR, as demonstrated in a podocyte-specific knockout mouse model.

This paper describes a mouse model with a human ADAR G1007R mutation that causes neuroinflammation and shows that deleting MDA5 can reverse brain inflammation.

This study identifies NuRD complex downregulation and altered proteostasis in quiescent ovarian cancer cells and shows that targeting these mechanisms can synergistically kill cancer cells.

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

This study shows that excess dietary sodium partially restores electrolyte imbalance and kidney injury markers in GRP170-deficient mice but not weight or tubule integrity.

The paper optimizes fluorogen-activating proteins (FAPs) for use in S. cerevisiae to enable quantitative endocytic studies and co-localization analysis of proteins.

The paper identifies a small-molecule stimulator of the human Hsp70-disaggregase system that selectively activates DnaJB1- or DnaJB4-containing chaperone complexes.

The paper identifies new disease-associated ROMK variants using genomic databases and computational tools, revealing distinct molecular defects in protein folding and function.

The paper develops a pipeline to predict protein targets for drug-like compounds using transcriptomics and machine learning, achieving 26% top-10 accuracy on FDA-approved drugs.