Annabel C. Beichman

The paper examines how reproductive longevity interacts with population size to shape germline mutation rates, finding that longer reproductive ages reduce mutation rates per year in sperm and eggs.

This study examines the distribution of fitness effects (DFE) across eleven animal species, finding that DFE co-varies with phylogeny and that mammals have more deleterious mutations than insects and birds.

The paper measures germline mutation rates in a family with MUTYH pathogenic variants, finding elevated C>A mutations in children of affected mothers but not fathers, suggesting maternal-specific mutator effects.

mutyper assigns mutation types to SNP data using ancestral genome estimates and computes mutation spectra for individuals and populations.

The paper identifies a natural mutator allele in mice that increases C>A germline mutations by 50% due to a variant of the Mutyh gene.