Vincent Michel

This study shows human coronavirus HKU1 replicates more efficiently at nasal temperature (33°C) than at body temperature (37°C), with differences in innate immune response and viral stability.

This study shows that the SARS-CoV-2 Omicron variant replicates more efficiently and evades innate immune responses in a nasal epithelium model at physiological temperature.

This study shows that the SARS-CoV-2 E protein's PDZ-binding motif enhances virulence by disrupting epithelial barriers and inflammation, but not neuroinvasion.

This study uses human lung organoid-on-chip models to compare host responses to Streptococcus pneumoniae and SARS-CoV-2 variants, showing strain-specific infection and immune responses.

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

This study characterizes SARS-CoV-2 variants XBB and BA.2.86/JN.1, finding they show increased fitness and antibody evasion while maintaining antiviral sensitivity.

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

This study investigates SARS-CoV-2 infection in the olfactory system, showing viral persistence and inflammation linked to prolonged loss of smell in COVID-19 patients.