Etienne Simon‐Lorière

This study shows human coronavirus HKU1 replicates more efficiently at nasal temperature (33°C) than at body temperature (37°C), with differences in innate immune response and viral stability.

The paper identifies novel SARS-CoV-2-related viruses in Cambodian bats, revealing genetic diversity and potential zoonotic risk through receptor-binding domain analysis and pseudovirus assays.

This study shows that a non-retroviral EVE suppresses viral replication in mosquitoes across life stages and generations but does not affect survival or reproduction.

This paper develops and validates a multiplex qRT-PCR assay to accurately quantify DENV serotypes in competition assays, revealing DENV-1's enhanced replicative fitness in vitro.

The paper identifies polygenic viral factors in African Zika virus strains that enhance mosquito transmission efficiency compared to Asian strains.

This paper modifies a measles vaccine by removing a viral protein to create a cancer immunotherapy that activates the immune system via RIG-I signaling, leading to tumor regression in multiple models.

The paper identifies a TUBB3+ cell population in TB granulomas across multiple species and patients, distinct from known cell types and present in other infections.

This study evaluates Tecovirimat's antiviral activity against four Mpox virus clades and finds it effectively inhibits all at nanomolar concentrations.

The paper evaluates the neutralization activity of two new monoclonal antibodies against emerging SARS-CoV-2 variants and finds reduced efficacy against some sublineages.

The paper analyzes neutralizing antibodies from vaccinated and hybrid immune individuals to show that restored B cell germlines enhance neutralization against SARS-CoV-2 variants like BA.2.86.

This study characterizes SARS-CoV-2 variants XBB and BA.2.86/JN.1, finding they show increased fitness and antibody evasion while maintaining antiviral sensitivity.

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

The paper assesses the neutralization of SARS-CoV-2 Omicron subvariants BA.2.86 and EG.5.1 by antibodies from prior infection or vaccination, finding comparable neutralization titres to XBB.1 and EG.5.1.

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.

This study uses genomic data from 8746 SARS-CoV-2 genomes across 33 African countries to show that most epidemics were initiated by European importations and later driven by local transmission and mobility, leading to the spread of variants of concern.

This study sequenced SARS-CoV-2 genomes from France to trace early introductions and spread, showing both imported cases and local circulation before widespread symptoms.

This study shows that genetic diversity in Collaborative Cross mice affects ZIKV infection outcomes, including viral replication and disease severity, independent of Oas1b.

The paper introduces CATCH, a method for designing compact and scalable probe sets to enhance metagenomic sequencing sensitivity, demonstrating improved viral genome recovery and diversity preservation.