Sandra Petrus-Reurer

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

This study generates HLA-edited cholangiocyte organoids with reduced immunogenicity and reports their mutation profiles and immune response in vitro and in vivo.

This study creates a single-cell atlas of human liver development, identifying pathways and factors that guide hepatic cell fates and improving hepatocyte-like cell functionality.

This study generates functional hepatocytes from human pluripotent stem cells using forward programming with nuclear receptors, bypassing the limitations of traditional differentiation methods.

This study maps the single-cell transcriptomic dynamics of hESC-RPE differentiation, identifies an intermediate progenitor, and shows in vivo maturation after transplantation.