Ludovic Vallier

This study shows that collagen I mechanical signaling in synthetic hydrogels promotes cholangiocyte differentiation and bile duct formation from hiPSCs.

This paper introduces GERALT, a genetic circuit that enables TGFβ-independent hiPSC renewal and inducible lineage programming, improving differentiation efficiency and reducing medium complexity.

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

The paper introduces Flufftail, a framework for fuzzy clustering in single-cell data, to infer gene regulatory network dynamics by leveraging membership probabilities and regulatory hub genes.

This study shows that both terminal misfolding and polymerisation of Z 1-antitrypsin contribute to liver disease phenotypes, with terminal misfolding driving pro-fibrotic responses and metabolic changes.

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

This study shows NGN3 protein oscillations control timing of human pancreatic endocrine differentiation, not fate, through fold-change detection via an incoherent feedforward motif.

This paper develops a 3D multicellular model of NAFLD using hiPSC-derived liver cells to study disease mechanisms and interactions.

This study creates a single-cell atlas of human liver development, identifying pathways and factors that guide hepatic cell fates and improving hepatocyte-like cell functionality.

This study generates functional hepatocytes from human pluripotent stem cells using forward programming with nuclear receptors, bypassing the limitations of traditional differentiation methods.

This paper presents a spatially resolved single-cell transcriptome atlas of human gastrulation, identifying novel cell types and revealing key differences from mouse gastrulation.

This study identifies cell cycle regulation as a driver of endothelial-to-haematopoietic transition using single-cell transcriptomics in a human pluripotent stem cell system.

The paper uses single-cell RNA-seq of differentiating iPS cells from 125 donors to identify expression quantitative trait loci influencing gene expression during endoderm differentiation.

This study investigates how cell cycle regulators influence mesoderm specification in human pluripotent stem cells, finding that CDKs and pRb phosphorylation are context-dependent for efficient mesoderm formation.

The paper uses single-cell profiling of expression and DNA methylation to study splicing regulation and heterogeneity in human induced pluripotent stem cells.

This study analyzes 522 human iPSCs to identify genetic sources of phenotypic variation, finding 5-25% of variation in traits like differentiation capacity is due to individual differences.