Jason K. Kim

The paper identifies a preoptic neurocircuit that modulates metabolic flexibility by shifting fuel use from glucose to fatty acids through insulin resistance in skeletal muscle.

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

This study shows that Rlim regulates diurnal rhythms of food intake and thermogenesis in mice by modulating specific GABAergic neurons in the SCN.

This study shows that targeting both DGAT2 in hepatocytes and FASN in stellate cells reduces NASH in mice more effectively than targeting either gene alone.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

This study shows that apoE-deficient mice have a reduced transcriptional response in visceral fat to high-fat diet, linked to increased metabolic efficiency and resistance to obesity.