Hiroshi Hamada

The paper investigates the localization and function of axonemal microtubule inner proteins and dynein docking complex members in vertebrate motile cilia, revealing structural and functional differences between (9+2) and (9+0) cilia.

The paper shows that immotile cilia in mouse node cells detect mechanical forces from leftward fluid flow, leading to asymmetric molecular responses that break left-right symmetry.

The paper identifies Bicc1 and Dicer1 as regulators of left-right patterning by posttranscriptionally repressing Dand5, a Nodal inhibitor, downstream of flow sensing.

The paper investigates how fluid flow induces asymmetric Dand5 mRNA decay in the mouse embryo through the Bicc1-Ccr4 RNA degradation complex.