Kevin Thurley

This study shows mechanical stress releases mitochondrial dsRNA, activating RIG-I to drive osteogenic differentiation and calcification in aortic disease, with JAK/STAT inhibition offering therapeutic potential.

SPARQ-MI provides a streamlined spatial single-cell analysis method for tumor microenvironments, revealing CD8 T cell state and spatial location associations with immunotherapy response.

This paper develops a homogenization approach to model cytokine diffusion and reaction dynamics in immune-cell environments, enabling efficient multiscale modeling by linking microscopic reaction-diffusion models to continuum approximations.

This study examines neutrophil infiltration patterns in lymph nodes during adoptive T cell therapy in mice, revealing differences between tumor-draining and non-tumor-draining lymph nodes.

This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.

The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.

This study uses simulations to show that spatial cytokine inhomogeneities in T cell populations are critical for paracrine signaling and depend on cell population properties and feedback mechanisms.

The paper develops a mathematical framework to analyze collective immune-cell dynamics and applies it to model Th1 vs. Tfh cell fate decisions in chronic inflammation.

The paper develops a mathematical model of plasma cell survival that integrates signaling and apoptosis pathways, revealing the essential roles of APRIL and stromal cell contact.

This study uses a spatial reaction-diffusion model to show that cytokine secretion patterns and receptor expression feedback shape spatial cytokine gradients in tissues.