Panayotis Verginis

This study shows ACOD1 deficiency in microglia enhances inflammatory responses by altering arginine metabolism, specifically increasing argininosuccinate synthesis while reducing polyamine synthesis, dependent on ACLY.

This study shows PD-L1 blockade in tumor-bearing mice targets bone marrow HSPCs, reprograms their transcriptome toward inflammation, and reduces myeloid-derived suppressor cells.

This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.