PD-L1 blockade immunotherapy rewires cancer emergency myelopoiesis
Athina Boumpas, Antonis Papaioannou, Pavlos Bousounis…·Panayotis Verginis
This study shows PD-L1 blockade in tumor-bearing mice targets bone marrow HSPCs, reprograms their transcriptome toward inflammation, and reduces myeloid-derived suppressor cells.