Author

Nicole R. Bracci

University of PennsylvaniaORCID 0000-0002-7298-4796Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Susan Reich WeissiD· 3 shared Ebba K. BlomqvistiD· 2 shared James M. BurkeiD· 2 shared Nicholas A. ParentiiD· 2 shared Abhishek AsthanaiD· 1 shared Anthony R. FehriD· 1 shared Chengjin YeiD· 1 shared Clayton J. OtteriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Susan Reich WeissORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 18, 2025

MERS-CoV antagonizes PKR activation by inhibiting its condensation at viral replication complexes

Ebba K. Blomqvist, Nicole R. Bracci, Helena Winstone…·James M. Burke

This study shows MERS-CoV inhibits PKR activation by blocking its condensation on viral dsRNA, revealing a mechanism by which the virus evades innate immune responses.

1 citation

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologyVirusesPeer-reviewedJan 16, 2025

Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung Derived Cell Lines

David M. Renner, Nicholas A. Parenti, Nicole R. Bracci, Susan Reich Weiss

This study compares how three betacoronaviruses interact with the PERK pathway of the integrated stress response, showing differences in their reliance on eIF2 dephosphorylation for replication.

7 citations

humanproteomics

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MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedApr 3, 2024

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

Clayton J. Otter, Nicole R. Bracci, Nicholas A. Parenti…·Susan Reich Weiss

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.

59 citationstop 1%

humanbulk RNA-seq

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