Author

Clayton J. Otter

University of PennsylvaniaORCID 0000-0003-1609-8105Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Susan Reich WeissiD· 3 shared L. H. TaniD· 2 shared Noam A. CoheniD· 2 shared Abhishek AsthanaiD· 1 shared Alejandra FaustoiD· 1 shared Alexander M. PriceiD· 1 shared Alison YuiD· 1 shared Anthony R. FehriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Susan Reich WeissORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 27, 2026

Inhibition of RNA splicing is a novel therapeutic strategy for disruption of nuclear replicating viruses

Lorenzo Serra, Claire M O'Brien, Molly R. Patterson…·Alexander M. Price

This study shows that inhibiting RNA splicing reduces viral replication in splicing-dependent viruses like adenovirus, HSV-1, and influenza A, suggesting a new antiviral strategy.

DOI 10.64898/2026.06.26.734849

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedMay 17, 2024

Interferon signaling in the nasal epithelium distinguishes among lethal and common cold respiratory viruses and is critical for viral clearance

Clayton J. Otter, David M. Renner, Alejandra Fausto…·Susan Reich Weiss

The paper examines how interferon signaling in nasal epithelial cells differentiates between common cold and lethal respiratory viruses, showing its role in viral clearance.

33 citationstop 4%

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedApr 3, 2024

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

Clayton J. Otter, Nicole R. Bracci, Nicholas A. Parenti…·Susan Reich Weiss

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.

59 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky