Maria Spies

This paper investigates how (AAGGG)n repeats in the RFC1 gene cause DNA replication fork stalling and reversal, implicating G4-DNA and SMARCAL1 in the process.

This study uses optical tweezers to analyze XPD helicase dynamics on DNA lesions, revealing distinct damage-sensing behaviors and identifying two XPD regions sensitive to DNA modifications.

This study investigates PARP1's interaction with G-quadruplexes using single-molecule techniques, revealing dynamic 1:1 binding and PARylation activation.

This study shows the Shu complex enhances RAD51 activity by stabilizing filaments and promoting RPA diffusion on ssDNA, with implications for cancer therapy.

This study generates a fluorescently labeled human XPA protein to study DNA binding dynamics during nucleotide excision repair.

The paper investigates how the single-stranded DNA binding protein RPA2 modulates the processivity of the XPD helicase through a switch mechanism.

This study identifies unique roles of RPA complexes in C. elegans meiosis, showing RPA-2 is essential for replication and repair, while RPA-4 inhibits RAD-51 and promotes apoptosis.