Gülçin Pekkurnaz

This study develops an agent-based model to show how mitochondrial shape, mechanics, and fission-fusion dynamics influence axonal transport and structural integrity.

This study identifies mitochondrial-derived double-stranded RNA as a source of RNA stress in aged neurons, which activates the ISR through PKR and contributes to neurodegeneration.

This study shows that neuronal activity increases mitochondrial O-GlcNAcylation, which helps neurons meet energy demands based on fuel availability.

FluxNorm normalizes metabolic flux data by in situ cell counting to accurately assess cellular bioenergetics across experimental conditions.

This study identifies OGT-mediated O-GlcNAcylation of HK1 as a mechanism regulating glycolytic metabolon assembly on mitochondria, enhancing ATP production and synaptic function.

The paper develops a 3D reaction-diffusion model to study how mitochondria-endoplasmic reticulum contact sites regulate calcium and ATP dynamics in postsynaptic spines.

This paper introduces a deep learning method to enhance the resolution and speed of point-scanning imaging systems by restoring undersampled images.