Author

David L. Sacks

National Institutes of HealthORCID 0000-0002-7557-3124Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Tiago Rodrigues FerreiraiD· 2 shared Andrea PauniD· 1 shared Angélica Hollunder KlippeliD· 1 shared Ariely Barbosa LeiteiD· 1 shared Bruno Souza BonifácioiD· 1 shared C. Eduardo Gomes Alves· 1 shared Carolina Catta-PretaiD· 1 shared Clara Lúcia BarbiériiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Tiago Rodrigues FerreiraORCID

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3 papers

Recent·Most cited

Evolutionary BiologyPLoS PathogensPeer-reviewedApr 29, 2026

Cryptic Sex in Leishmania Depends on SPO11 Paralogs

Carolina Catta-Preta, Vitor Luiz da Silva, Claudio Meneses…·David L. Sacks

This study identifies the roles of SPO11 paralogs in Leishmania hybridization, showing they are essential for efficient mating and genome segregation.

DOI 10.1371/journal.ppat.1014181

experimental assaycell type annotation

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ImmunologyNature CommunicationsPeer-reviewedApr 1, 2025

Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

Gabriela Pessenda, Tiago Rodrigues Ferreira, Andrea Paun…·David L. Sacks

The paper shows that macrophage heterogeneity, including resKC-derived and monocyte-derived cells, is critical for granuloma maturation and parasite control in visceral leishmaniasis.

26 citationstop 1%

mousebulk RNA-seq

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MicrobiologyMolecular MicrobiologyPeer-reviewedJan 1, 2025

Functional characterization of N-acetyltransferase 10 (NAT10) in Leishmania mexicana

Suellen Rodrigues Maran, Ariely Barbosa Leite, Gabriela Gomes Alves…·Nilmar Silvio Moretti

This study characterizes NAT10 in Leishmania mexicana, showing its nuclear localization, essentiality, and role in parasite differentiation and metabolism.

3 citations

mouseproteomics

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