Author

Brea C. Lipe

University of Rochester MedicineORCID 0000-0002-7596-2015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Brendan F. BoyceiD· 2 shared Hengwei ZhangiD· 2 shared Lianping XingiD· 2 shared Jianguo TaoiD· 1 shared Jiatong LiuiD· 1 shared Jie SheniD· 1 shared Jiongnan Xu· 1 shared Jun ZhangiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Brendan F. BoyceORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 4, 2023

Post-translational regulation of Platelet-derived growth factor receptor β is critical for fracture repair in aged mice

Jianguo Tao, Brea C. Lipe, Brendan F. Boyce…·Hengwei Zhang

This study identifies PDGFRβ as a target of proteasome inhibitors in aged mice, showing that its degradation impairs fracture repair and that combined PDGF-BB and proteasome inhibitor treatment improves repair.

DOI 10.1101/2023.11.04.565143

mouseproteomics

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Cell BiologybioRxivPreprintNov 1, 2023

Senescent cells impair fracture repair through elevating ubiquitin-proteasome system activity in aged mice.

Jun Zhang, Jiongnan Xu, Jiatong Liu…·Hengwei Zhang

This study shows senescent cells impair fracture repair in aged mice by increasing ubiquitination of PDGFRβ via TGFβ, suggesting a new therapeutic target.

1 citation

mouseproteomics

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