Arif Yurdagul

This study shows EHD1 promotes inflammation and stabilizes sortilin in macrophages, accelerating atherosclerosis through enhanced TNFR2-NF-kB signaling and endocytic recycling.

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

This study shows fibronectin-binding integrins drive ER stress in endothelial cells under atherogenic conditions, promoting inflammation through JNK-c-Jun signaling.

This study shows that lipin-1 limits macrophage lipid synthesis, which supports inflammation resolution by enhancing efferocytosis.

This study shows that MK2 inhibitors TBX-1 and TBX-2 improve glucose metabolism and reduce atherosclerotic plaque instability in mice with established atherosclerosis.