David Levens

The paper develops a genetic tool to distinguish MYC's activation from amplification of gene expression and reveals that DNA supercoiling stabilizes pre-initiation complexes, enhancing MYC-driven transcription.

SpacePhenotyper transfers predictive gene-phenotype relationships from bulk data to spatial transcriptomics to analyze clinical phenotypes in tumor regions.

This study shows that reducing endogenous Myc levels in p53-deficient mice extends tumor-free survival and that tumors compensate by increasing Myc dosage or expression.

This study identifies AGO1 as a tumour suppressor in Drosophila that represses Myc transcription, inhibiting cell and tissue growth through direct transcriptional repression.

The paper identifies Psi as a repressor of developmental pathways that promotes Drosophila wing growth by both activating Myc and repressing growth inhibitors.