Kazuto Kobayashi

The paper investigates how thalamocortical pathways from the basal ganglia and cerebellum route credit signals to cortical circuits, revealing anatomical segregation and plasticity mechanisms that enhance learning.

This study shows that cholinergic modulation between brain hemispheres enables paw preference switching in mice through experience-driven changes in neural activity.

The paper shows that prior auditory learning inhibits somatosensory responses in mice through ACC-S1 projections, promoting blocking of redundant associations.

This study shows that the orbitofrontal cortex promotes alloparental caregiving in female mice by modulating dopamine dynamics during behavior acquisition.

The paper shows that opioidergic signals in the medial prefrontal cortex activate the descending pain inhibitory system to initiate placebo analgesia in neuropathic pain rats.

This study shows that two thalamostriatal systems in common marmosets have distinct roles in visual discrimination learning, with one affecting reversal learning and the other impacting task acquisition.

This study shows that different striatal subregions, aDLS and pVLS, use distinct processes to mediate auditory discrimination learning in rats.

This paper develops a method to activate specific neurons in the mammalian brain using peripheral administration of ligand precursors, demonstrating its effectiveness in inducing neurotransmitter release and behavioral responses.

The paper shows emotional association enhances perceptual memory through BLA-frontal projections during NREM sleep by increasing coordinated reactivation and disrupting memory retention when BLA inputs are silenced.

The paper characterizes TH-Cre knock-in rats generated via Combi-CRISPR, showing cell type-specific Cre expression and normal catecholamine metabolism and behavior.

The paper records and manipulates maternal oxytocin (OT) neural activities in mice using fiber photometry and identifies plasticity and modulatory circuits.

This study identifies two sublayers in mouse insular cortex layer 5 with opposing roles in appetitive behavior through optogenetic activation.

The paper introduces a DIO/USS system to enhance Cre-dependent transgene expression specificity by preventing Cre-independent recombination during vector production.

The paper shows that restoring gamma oscillations in the limbic system via olfactory bulb neuromodulation alleviates depressive-like behaviors in animals.

This study shows that activating locus coeruleus norepinephrine neurons enhances aversive memory retrieval in mice.

The paper investigates context-dependent differences in orienting and defense-like responses mediated by distinct pathways in the superior colliculus using optogenetic activation in mice.

The paper identifies a novel GABAergic neuron population in the olfactory cortex of mice that project to the lateral hypothalamus and integrate olfactory and top-down inputs.

The paper uses multivariate mutual information analysis on sc-RTqPCR data to estimate the k-dimensional topology of gene expression profiles in midbrain neurons, revealing complex combinatorial structures and regulatory principles.