Romain Durand

The paper uses deep mutational scanning to analyze resistance mutations in Fks1, revealing distinct resistance landscapes for echinocandins and triterpenoids, including a novel triterpenoid-specific hotspot.

This study identifies CtiC, a fertility inhibitor encoded by SGI1 that blocks conjugative transfer of IncA/C plasmids by interfering with relaxosome assembly.

The paper shows that resistance mutations to antifungal drugs are conserved across fungal species but epistasis limits their transferability.

The paper identifies key residues in Fks hotspots that confer echinocandin resistance in Saccharomyces cerevisiae using molecular dynamics and deep-mutational scanning.

gyoza is a Snakemake workflow that simplifies the analysis of deep-mutational scanning data into functional impact scores with quality control and reporting.

The paper curates AMR mutations in fungi to create FungAMR, identifies universal resistance mutations, and provides a tool to screen genomes for AMR mutations.

The paper presents a cost-effective method for constructing barcoded libraries for genes of any length using low-cost DNA synthesis and standard cloning technologies.

This study identifies two distinct pathways for resistance to the antifungal 5-FC in yeast, showing that ecological factors influence which resistance mechanisms dominate.

The paper investigates the role of SgaCD in SGI1 mobilization, showing it activates AcaCD-responsive promoters and is essential for SGI1 excision, replication, and destabilization of IncC plasmids.