Ke Xu

This study shows PFOS worsens atherosclerosis by expanding Bacteroides caecimuris, altering bile acids, and activating FXR-TLR3 signaling in the gut.

StructureSAFE is a chemical language model that combines protein structure and evolutionary information with molecular representations to improve hit identification and lead optimization, achieving state-of-the-art performance in chemical plausibility and binding affinity prediction.

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.