Alexander Y. Payumo

This study uses digital holographic imaging to show that mononucleated cardiomyocytes retain proliferative potential while binucleated cells have limited capacity to divide, with size thresholds affecting division ability.

The paper investigates the roles of glucocorticoid and vitamin D receptors in cardiomyocyte proliferation, finding that while they inhibit proliferation in vitro, they are not essential for cell-cycle exit in vivo.

This study shows that sympathetic nerve activity reduces cardiomyocyte proliferation and causes binucleation, which may limit heart regeneration in adults.