James B. Hurley

This study investigates how chronic hypoxia reprograms metabolism and alters redox and lipid homeostasis in rod photoreceptors using a mouse model.

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

This study shows that enzymatic assays overestimate β-hydroxybutyrate (β-HB) in RPE cultures, while mass spectrometry reveals equal apical and basal secretion and β-HB sources from fatty acids and amino acids.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.