Daniel T. Hass

This study investigates how chronic hypoxia reprograms metabolism and alters redox and lipid homeostasis in rod photoreceptors using a mouse model.

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

This study shows that enzymatic assays overestimate β-hydroxybutyrate (β-HB) in RPE cultures, while mass spectrometry reveals equal apical and basal secretion and β-HB sources from fatty acids and amino acids.

This study shows that increasing Ucp2 expression in retinal ganglion cells protects against glaucoma-induced cell death, but transcriptional activation alone is insufficient for neuroprotection.

This study shows that deleting UCP2 in mice reduces retinal ganglion cell death in glaucoma by increasing mitophagy and mitochondrial quality control.