Rayne R. Lim

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

This study shows that retinal microglia-derived S100A9 activates the NLRP3 inflammasome in Western diet-fed Ossabaw pigs, contributing to diabetic retinopathy.

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.