Jonas Mühle

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

The paper presents the first X-ray structure of an NtA-mediated asymmetric BRAF dimer bound to MEK1, showing it is a catalytically active state, not an intermediate in BRAF activation.

The paper determines the crystal structure of Egalitarian bound to an mRNA localization signal, revealing structural features essential for RNA recognition and function.

This study shows that the all-trans 6.11 retinal analogue activates the invertebrate bistable opsin JSR1 and enables complex formation with downstream signaling partners.

This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.

This study tests a dimeric prion protein ligand as a therapy for peripheral demyelination but finds it fails to rescue myelinopathy in PrP-deficient mice.