Matthew J. Rodrigues

The paper develops a macrocyclic peptide WJL-63 with high ACE2-binding affinity and characterizes its structure and potential for imaging applications.

This study uses room-temperature serial crystallography to observe time-dependent ligand dynamics of the β-lactamase CTX-M-15 with avibactam, revealing conformational changes critical for inhibitor reformation.

This study presents active state structures of a bistable opsin, JSR1, bound to G proteins, revealing differences in activation mechanisms between monostable and bistable opsins.

This study shows that the all-trans 6.11 retinal analogue activates the invertebrate bistable opsin JSR1 and enables complex formation with downstream signaling partners.

This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.