Xavier Deupí

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

This paper introduces optoDRD1, a photoswitchable optoGPCR that reversibly controls Gs signaling and arrestin recruitment using distinct wavelengths of light.

The paper develops a macrocyclic peptide WJL-63 with high ACE2-binding affinity and characterizes its structure and potential for imaging applications.

This study identifies a novel chloride counterion mechanism in coral opsins that stabilizes the Schiff base proton, enabling light sensitivity without a traditional counterion residue.

This study presents active state structures of a bistable opsin, JSR1, bound to G proteins, revealing differences in activation mechanisms between monostable and bistable opsins.

This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.

This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.

The paper demonstrates that the ER/K motif (SAH) can rigidly connect protein domains, enabling the formation of ordered crystals and new applications in protein nanotechnology.