Author

Ilaria Puoti

University of DundeeORCID 0000-0002-7779-4393Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Alessio CiulliiD· 2 shared Giorgia KiddiD· 2 shared Kirsten McAulayiD· 2 shared Vesna VetmaiD· 2 shared Aileen B. FrostiD· 1 shared Andrea Stingu· 1 shared Angus D. CowaniD· 1 shared Anju Kombara· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

Alessio CiulliORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintDec 22, 2025

Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation

Suzanne O’Connor, Zoe J. Rutter, Angus D. Cowan…·Alessio Ciulli

This study identifies CRBN binders that induce or fail to induce CRBN closure, showing that closure is critical for degrader activity.

1 citation

humanstructural biology

𝕏 PostBluesky

Cancer BiologyACS Chemical BiologyPeer-reviewedJul 3, 2024

Confounding factors in targeted degradation of short-lived proteins

Vesna Vetma, Laura Casares Perez, Ján Eliaš…·Manfred Koegl

This study shows that the natural half-life of a target protein significantly affects degradation by degrader agents and highlights confounding factors in screening for protein degraders.

53 citationstop 2%

statistical modeldrug response / drug discovery

𝕏 PostBluesky