Author
University of DundeeORCID 0000-0002-7500-2276Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
James B. Shaum, Miquel Muñoz i Ordoño, Erica A. Steen…·Michael A. Erb
This study uses high-throughput chemistry to discover chemical inducers of proximity by modifying pre-existing ligands and screening for degrader activity.
Suzanne O’Connor, Zoe J. Rutter, Angus D. Cowan…·Alessio Ciulli
This study identifies CRBN binders that induce or fail to induce CRBN closure, showing that closure is critical for degrader activity.
Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter…·Alessio Ciulli
The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.