Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis
Emma Gazzara, José M. Adrover, A. Lui, S. Han, Zakeria Aminzada, N. Bhandari, Nicole Sivetz, V. S. Shirue, Bhupinder S. Shergill, M. B. Curtis, Steven C. George, Alexander Cicala, Arvind Rishi, C. Chung, Craig Devoe, , Sepideh Gholami
This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.
bioRxiv · May 30, 2025 · PreprintCancer Biology