Yoshikazu Tanaka

This paper engineers α-hemolysin to enable selective recognition, covalent linkage, and chemical exchange between artificial cells through a single protein system.

This study defines the assembly pathway of CipB, showing that a 24-mer precursor forms and packs into a cubic lattice, with N-terminal flexibility enabling crystallization.

This study identifies montanine as a potent antiviral compound that inhibits RNA viruses by targeting translational elongation and GCN1-related stress responses.

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

This study determines the X-ray crystal structure of SxPT1, a prenyltransferase, and discusses its catalytic mechanism for indole prenylation.

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

This study shows the glomerulus actively transports tumor-derived extracellular vesicles into urine, revealing a mechanism for their excretion and potential use in cancer diagnostics.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.