Homeira Moradi Chameh

This paper develops laser-integrated nanophotonic neural probes with on-chip sensors for scalable photostimulation and feedback monitoring in optogenetic experiments.

This study identifies somatic Ras-MAPK pathway variants in hippocampal tissue from patients with drug-resistant epilepsy, showing their association with clonal competition and worse surgical outcomes.

This paper introduces multifunctional nanophotonic neural probes that combine photostimulation, electrophysiology, and microfluidic delivery for in vivo use in mice.

The paper shows that within-cell-type electrophysiological heterogeneity is malleable and can be restored by blocking HCN currents in epilepsy models.

This paper introduces implantable nanophotonic neural probes that enable patterned photostimulation and electrophysiology recording with minimal thermal damage.

The paper models the effects of 5-PAM on human cortical microcircuits to assess its potential in treating depression and identifies EEG biomarkers for drug efficacy.

The paper investigates the role of hyperpolarization-activated currents in shaping spiking frequency preference of human cortical layer 5 neurons using computational models and experimental validation.

The paper identifies age-related increases in sag voltage amplitude in human pyramidal neurons and shows reduced baseline firing in older neuron microcircuits.

The paper shows that reduced neuronal heterogeneity in epileptogenic tissue decreases network resilience to synchrony changes, leading to seizure-like dynamics.

The paper models human cortical microcircuits to show reduced inhibition in depression impairs stimulus processing by increasing baseline activity and reducing signal-to-noise ratio.

The paper characterizes electrophysiological diversity among human cortical pyramidal neurons by analyzing sag currents and frequency preferences across different cortical layers.

The paper develops a biophysically detailed human layer 5 cortical neuron model showing slower h-current kinetics compared to rodents, leading to differences in resonance and post-inhibitory rebound.

The paper uses computational models to show that hyper-excitable inhibitory networks can transition from asynchronous to synchronous activity, potentially explaining seizure initiation.