Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma
Abhishek K. Singh, Balkrishna Chaube, Kathryn M. Citrin…·William C. Sessa
This study shows that loss of NgBR/cis-PTase function in the liver leads to fatty liver disease that progresses to hepatocellular carcinoma with 100% penetrance, and DGAT2 inhibition prevents this progression.