Ziqiang Guan

This study identifies DrmA, a DUF998 family protein, as a regulator of cationic glycolipid levels and a contributor to high-level daptomycin resistance in E. faecalis.

This study identifies anionic bacterial sphingolipids, specifically ceramide phosphoglycerate, and shows they increase membrane zeta potential and stiffness.

This study identifies the biosynthetic genes for glucosaminyl phosphatidylglycerol (GlcN-PG) in Pseudomonas aeruginosa and demonstrates their role in its production and potential transport.

This study shows human gut bacteria can synthesize fluoroalkyl-containing membrane lipids in response to PFOA exposure, suggesting new pathways for PFAS bioaccumulation and host-microbe interactions.

This study identifies two functional ornithine lipid synthases in Vibrio cholerae and shows their roles in OL synthesis under phosphate limitation and low salinity.

The paper identifies CpgD as a phosphoglycerate cytidylyltransferase essential for ceramide diphosphoglycerate synthesis in Caulobacter crescentus.

This study identifies two inhibitors of the Mtb efflux pump EfpA, determines their binding mechanisms, and suggests their potential for combination anti-tuberculosis therapy.

This study identifies TamL as essential for outer membrane integrity in Bacteroidetes, showing its role in maintaining membrane stability and interacting with TamB.

The paper uses sequence data and machine learning to identify novel substrates and lipid products of MprF in bacteria.

This study investigates the biosynthesis and roles of glycolipids in mitis group streptococci, showing their importance in virulence and antibiotic resistance.

The paper investigates the subcellular localization of bacterial sphingolipid synthesis enzymes to determine the order of reactions in the pathway.