Stephan E. Lehnart

The paper examines the relationship between the ER and SR in cardiac myocytes, finding that the SR becomes the primary site of protein synthesis in adult cells, while the ER retains specialized functions.

The paper reconstitutes synthetic ribbon-type active zones in HEK293 cells using Bassoon, RIBEYE, and CaV1.3 channels, showing structural and functional similarities to native ribbons.

This paper introduces a computational method to analyze sarcomere properties in human cardiomyocytes using radial frequency spectra, showing its effectiveness in detecting molecular differences in cardiac diseases.

This study uses super-resolution imaging to reveal the dynamic nanoscale architecture of CaV1.3 channel clusters in cardiac myocytes, showing mobile channels within nanodomains rather than dense packing.

This paper introduces a microfluidics platform for multiplexed super-resolution microscopy, demonstrating its use in imaging cancer and cardiac cells with high reproducibility.

This study uses mCherry-titin mice to visualize sarcomere dynamics during skeletal muscle development and injury repair, revealing titin mobility and localization patterns in myocytes.

The paper introduces mCP, a streamlined workflow for detecting protein complexes with reduced fractionation, and demonstrates its application in analyzing cardiac tissue.