Helge Großhans

The paper identifies MEP-1 as a novel substrate of DPF-3, showing cleavage after threonine and demonstrating its impact on reproductive fitness.

The paper shows that large transgene arrays in C. elegans cause transcriptional dysregulation and synthetic molting defects when combined with a myrf-1 mutation.

The paper identifies let-7 miRNA and lin-46 mRNA as the essential targets of LIN28 in C. elegans, showing they regulate developmental timing through coordinated control.

This study identifies a conserved signaling module involving LIN-42 and KIN-20 that regulates molting timing in C. elegans, mirroring the mammalian PER-CK1 complex.

The paper develops a linear model to predict chromatin dynamics based on transcription factor binding in C. elegans, identifying key regulators that schedule gene expression rhythms.

The paper develops qPISA to quantify protease substrate turnover, revealing subsite cooperativity in DPP4 and distinguishing it from DPF-3.

The paper identifies TRIM71's mechanism of mRNA silencing through recruitment of TNRC6/GW182 and shows competition among silencing pathways.

The paper identifies GRH-1 as a transcription factor essential for rhythmic molting in C. elegans, showing its role in gene regulation and cuticle formation.

The paper identifies a mechanism in C. elegans that maintains size uniformity by coupling growth rate and developmental duration through an oscillator.

The paper identifies BLMP-1 as a transcription factor that promotes oscillatory gene expression to regulate timely molting in C. elegans.

The paper shows that proteolytic processing of Argonaute proteins by DPF-3 regulates small RNA association, maintaining genome integrity and fertility in C. elegans.

The paper characterizes a gene expression oscillator in C. elegans larvae, showing it starts in embryos, arrests transiently, and ceases in adults, operating near a SNIC bifurcation.

The paper identifies two LIN-29 isoforms that regulate distinct aspects of the juvenile-to-adult transition in C. elegans through differential spatiotemporal expression and regulatory control by LIN-28, LIN-41, and HBL-1.

The paper shows let-7 miRNA promotes adult development in C. elegans by releasing LIN41 repression of multiple transcriptional targets involved in sexual organ development and skin progenitor cell fate changes.

The paper identifies a regulatory pathway controlling the timing of sexual differentiation in C. elegans and shows its conservation in mice and humans.

The paper shows that miRNA activity and specificity depend on both target site architecture and miRNA abundance, challenging the binary view of target site functionality.