Dimos Gaidatzis

The paper shows that large transgene arrays in C. elegans cause transcriptional dysregulation and synthetic molting defects when combined with a myrf-1 mutation.

The paper identifies let-7 miRNA and lin-46 mRNA as the essential targets of LIN28 in C. elegans, showing they regulate developmental timing through coordinated control.

The paper develops a linear model to predict chromatin dynamics based on transcription factor binding in C. elegans, identifying key regulators that schedule gene expression rhythms.

The paper develops qPISA to quantify protease substrate turnover, revealing subsite cooperativity in DPP4 and distinguishing it from DPF-3.

The paper identifies BLMP-1 as a transcription factor that promotes oscillatory gene expression to regulate timely molting in C. elegans.

The paper identifies a pathway in C. elegans where LSM2-8 and XRN-2 selectively degrade H3K27me3-marked genes, revealing a new layer of heterochromatin regulation in animals.