Sophie Dumont

This study shows mammalian metaphase kinetochores are elastic and require condensin for structural stability and microtubule attachment under force.

This paper introduces a computational pipeline to quantify kinetochore morphology in live cells, showing it better captures shape changes than traditional metrics.

The paper uses microneedle manipulation to show that anaphase spindle midzone bundles transmit force both locally and globally, revealing their mechanical coupling and role in chromosome segregation.

This study investigates how NuMA activates dynein and regulates microtubule dynamics during mitosis using structural and functional analyses.

This study shows that mechanical force causes local damage and remodeling of spindle microtubules, leading to stabilization under force.

This study identifies a biophysical mechanism for mitochondrial pearling, showing it occurs spontaneously in various cell types and is driven by internal pressure or external tension.

This study shows NuMA reinforces the spindle mechanically through microtubule crosslinking, independent of dynein, by bundling microtubules and stabilizing spindle poles under force.

This study shows SKAP reduces friction at the kinetochore-microtubule interface and enhances attachment stability under force through its microtubule binding.

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

The paper shows that long chromosomes experience delayed error correction during mitosis due to increased polar ejection force, which can falsely stabilize incorrect attachments.