Ahmet Yıldız

This study investigates how tau protein regulates motor proteins on microtubules using single-molecule imaging, cryo-EM, and MD simulations, revealing distinct mechanisms for inhibiting kinesin-1 and dynein.

Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.

This study uses MINFLUX to track yeast dynein stepping dynamics at high resolution, revealing ATP hydrolysis per step and 8 nm steps with transient plus-end movements.

The paper investigates how microtubule lattice spacing affects MAP binding and kinesin-1 motility, revealing that lattice spacing, not tubulin PTMs, primarily regulates these processes.

This study shows CDK1-dependent phosphorylation of NuMA's N-terminus is essential for dynein-dynactin-NuMA complex formation, ensuring accurate chromosome segregation.

This study investigates how NuMA activates dynein and regulates microtubule dynamics during mitosis using structural and functional analyses.

The paper introduces a mechanism-aware platform to determine functional viral enzyme thresholds, revealing differences in stoichiometric requirements and enabling antiviral hypersensitivity detection.

This study identifies MAP9 as a microtubule stabilizer that promotes neuronal morphogenesis and differentially regulates kinesin motor activity.

This study shows that kinesin-1 can generate collective forces efficiently under low radial forces, challenging previous views on its detachment behavior.

This study shows NuMA reinforces the spindle mechanically through microtubule crosslinking, independent of dynein, by bundling microtubules and stabilizing spindle poles under force.

The paper shows Nde1 enhances Lis1 binding to autoinhibited dynein, facilitating Phi conformation opening through a novel intermediate state.

This study uses molecular dynamics simulations to analyze how Omicron mutations affect nanobody binding to the SARS-CoV-2 RBD, revealing structural changes and reduced binding stability.

This study investigates how HURP regulates Kif18A motility and microtubule dynamics during mitosis using single-molecule imaging and Cryo-EM.

This study investigates how the shelterin complex protects the telomeric junction by bridging single- and double-stranded telomeric DNA, enhancing POT1 binding stability and junction protection.

The paper shows that adaptors like BICDR1 and HOOK3 recruit two dyneins to dynactin, increasing force and speed compared to BICD2's single dynein recruitment.