Roy Parker

This study shows METTL3 inhibition reduces macrophage type I interferon response, increasing susceptibility to coronavirus infection.

The paper identifies ZNF346 as a regulator of PKR activation by analyzing the composition of dRIFs and their functional roles in dsRNA response regulation.

The paper identifies two types of Pol II disassociation regions, differing in base composition and sensitivity to cellular perturbations.

This study shows polyserine domains self-assemble and interact with tau to form sites of aggregation, accelerating tau fibrilization in vitro.

The paper investigates the role of G-tract RNAs and the DHX36 helicase in stress granule formation, finding that G-tracts do not influence mRNA partitioning into stress granules, and DHX36 limits stress granule formation by unwinding G-quadruplexes.

This study shows that polyserine peptides are toxic and worsen tau pathology in mice, supporting their role in human tauopathies.

The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.

The paper investigates the role of m6A modification in mRNA partitioning into stress granules and finds that m6A has limited effects on this process.

The paper identifies Hnrnpa2b1 as a key RBP regulating myogenic differentiation through post-transcriptional control in skeletal muscle regeneration.

This study shows stress granules promote chemoresistance by inducing cellular quiescence through cell-cycle exit.

The paper shows that tau aggregates in cells and brains contain RNA and alter nuclear speckle components, affecting pre-mRNA splicing.

The paper shows that RNA partitioning into stress granules depends on the combined effects of multiple interactions rather than single dominant ones.

The paper investigates how defects in the ubiquitin-proteasome system affect mRNA translation and partitioning into stress granules during acute stress.

The paper introduces dsRNA-Seq, a method to identify RNA viruses by sequencing double-stranded RNA, and demonstrates its effectiveness in detecting viral infections in mammals and reptiles.

The paper images single mRNA interactions with stress granules and P-bodies during stress, showing dynamic and stable associations influenced by mRNA length and granule size.

The paper examines mRNP architecture under translating and stress conditions, revealing mRNP compaction and end proximity changes in non-translating states.