NeurosciencebioRxivPreprint
Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates.
Carolyn J. Decker, Kathleen L. McCann, Evan Lester…·Roy Parker
1 citation
Author
Meaghan Van Alstyne
Howard Hughes Medical InstituteORCID 0000-0002-9939-5705Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 20 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- NeuroscienceScience AdvancesPeer-reviewed
Synaptic imbalance and increased inhibition impair motor function in SMA
Emily V. Fletcher, Joshua I. Chalif, Travis M. Rotterman…·George Z. Mentis
This study shows that unbalanced excitation-inhibition neurotransmission in SMA mice impairs motor function, and reducing inhibition improves neuronal function and behavior.
7 citationstop 4% - NeurosciencebioRxivPreprint
A chemical screen identifies p38 MAPK inhibition as a candidate neuroprotective strategy for combinatorial SMA therapy
Maria Jose Carlini, Jorge Espinoza‐Derout, Meaghan Van Alstyne…·Livio Pellizzoni
This study identifies p38 MAPK inhibition as a neuroprotective strategy that synergizes with SMN upregulation to improve motor function and survival in SMA mice.
1 citation - NeurosciencebioRxivPreprint
Polyserine peptides are toxic and exacerbate tau pathology in mice
Meaghan Van Alstyne, Vanessa L. Nguyen, Charles A. Hoeffer, Roy Parker
This study shows that polyserine peptides are toxic and worsen tau pathology in mice, supporting their role in human tauopathies.
4 citations - NeurosciencebioRxivPreprint
Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation
Evan Lester, Meaghan Van Alstyne, Kathleen L. McCann…·Roy Parker
The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.
DOI 10.1101/2022.09.22.509111 - NeuroscienceCell ReportsPeer-reviewed
SMN controls neuromuscular junction integrity through U7 snRNP
Sarah Tisdale, Meaghan Van Alstyne, Christian M. Simon…·Livio Pellizzoni
This study identifies a role for SMN in maintaining neuromuscular junction integrity through U7 snRNP function in SMA mice.
31 citationstop 5% - NeuroscienceCell ReportsPeer-reviewed
Stasimon contributes to the loss of sensory synapses and motor neuron death in a mouse model of spinal muscular atrophy
Christian M. Simon, Meaghan Van Alstyne, Francesco Lotti…·Livio Pellizzoni
This study shows that Stasimon overexpression in SMA mice improves motor function by preventing synaptic loss and motor neuron death through mechanisms involving p53 regulation.
64 citationstop 5%