F. Gisou van der Goot

This study shows that CLIMP-63's luminal domain forms flexible trimers and its cytosolic tail mediates clustering, together determining ER sheet width.

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

The paper identifies functional roles of human KZFPs through overexpression screening and integrative analysis, revealing diverse mechanisms in cellular homeostasis.

This study identifies S-acylation-deacylation cycles as regulators of CMG2 biogenesis and function, showing APT2 inhibition can block anthrax toxin entry and Collagen VI degradation.

The paper identifies the Lipid Oxygen Radical Defense (LORD) pathway and shows it is epigenetically controlled, affecting oxidative stress and ferroptosis.

This study shows that ANTXR2 regulates COL6 turnover in skeletal muscle, and its deficiency leads to ECM stiffening and muscle dysfunction.

This study identifies ANTXR2 as the receptor for C. perfringens NetF toxin, revealing structural insights into its binding mechanism and pore formation.

This study shows that CMG2 is essential for intestinal stem cell renewal after injury, as its loss impairs stem cell regeneration and Wnt signaling in mice.

This study identifies POU5F1B as a human-specific oncoprotein that enhances cell invasiveness via plasma membrane remodeling through ubiquitination and S-acylation.

The paper identifies a mutation in Cdc42 that causes a severe autoinflammatory syndrome by trapping the protein in the Golgi and disrupting its membrane interaction.

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.