Patrick A. Sandoz

The paper identifies immune cell subsets with distinct functional behaviors based on plasma membrane order using biophysical profiling and transcriptome analysis.

Tumors shape the hierarchy of CD155-CD112 receptors, reducing TIGIT blockade efficacy, while CD226 drives NK infiltration and shows binding plasticity.

This paper introduces a thermoplastic chip for single-cell immune assays that enables screening and high-resolution imaging of immune cell responses in 2D and 3D cultures.

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.